ChunGuang LI

Name: Dr. Chun Guang. Li

Sex: Male

Date of Birth: 11 Feb 1957

Nationality: Australian

Address: Department of Medical Laboratory Science, RMIT University,

Melbourne, Victoria 3001, Australia

Current Appointment

RMIT Senior Research Fellow, Dept. of Medical Laboratory Science, Faculty of Medical & Health Sciences, RMIT University

I currently manage a research group of 8 people, including 6 M.Sci and Ph.D students and 2 Postdoctoral fellows.

Research Funds obtained: $ 809,616

Previous Appointments:

1984-1986: Assistant Lecturer, Hebei Med University

1988-1991: Tutor & Demonstrator, Dept. of Pharmacol, Uni. of Melbourne

1991-1993: Research Fellow, Dept of Pharmacology, Uni. of Melbourne

1993-2000: Research Fellow/Senior Research Fellow, Dept of Med Lab Sci, RMIT

1996: Visiting Senior Research Fellow, University of Kumamoto, Japan

1997: Visiting Senior Scientist, University of Nevada, Reno, U.S.A.

Academic Background

Qualifications:

Ph.D. (1990), University of Melbourne

M. Med. (1984), Hebei Medical University

B. Med. (1982), Hebei Medical University

Professional Awards:

1986-1990 University of Melbourne Postgraduate Scholarship

1988 Australian Heart Foundation Travel Award

1989 ASCEPT Postgraduate Award

1990 ASCEPT postgraduate Award

1994 Austalian Society of Clinical and Experimental Pharmacologists

Postdoctoral Award

1994 International Society of Hypertension (ISH) Congress Astra Award

1996 ASCEPT Johnson-Johnson Award

1996 Australian Academy of Science. Japan Exchange Award

1997 Ramaciotti Foundation Award (U.S.A.).

Other Awards:

1998 Inclusion in World Who's Who International Professionals, Cambridge, UK.

2000 Inclusion in Who's Who in the World, 18th Edition, Marquis, USA

Research Experience On Chinese Medicine

Basic Research

I have initiated and/or carried out several projects related with investigation of pharmacological actions of various Chinese medicinal herbs and their products, including ginseng and ginsenosides, a range of F-CO compounds which were derived from a Chinese herbal extract. Various in vitro and in vivo techniques in laboratory animals as well as biochemical and electron microscope techniques were used. We demonstrated that nitric oxide is involved in the cardiovascular actions of ginsinosides. Since nitric oxide is a newly discovered molecular with a wide range of actions such as control of vascular functions, modulation of neurotransmission and immunoresponses this finding may provide new mechanism for the actions of certain herbs. Currently I am investigating the anticancer actions of a herbal formula on prostate cancer. This project is collaborated with Dr. M. Fabiani in the Austin Hospital of University of Melbourne, Australia. A range of modern molecular biology techniques will be used, including gene expression and immunohistochemistry for NOS and KAI1.

Chinese Medicine and Information technology

I have been interested in aspects of combination of Chinese Medicine with modern information technology. Currently I am developing a comprehensive database for Chinese medicinal herbs/products using a Structured Information Manager (SIM) system. SIM provides an SGML repository for storing and retrieving arbitrary SGML (or XML) and a number of services, including a web server for accessing that repository. It is expected a bilingual database (English and Chinese) will be developed to provide web-based updated information on Chinese herbs/products.

Profile

I have been actively involved in medical research and teaching for almost 16 years. I have developed sound knowledge and broad experience in the relevant fields. I published widely in high standard international referred journals. My research publications have been cited worldwide (>1,000 citations between 1991-1998, Scientific Citation Index, USA).

Invited lectures and Seminars:

April, 1993, The Australian Neuroscience Society, Uni. of Melbourne, Personal Invitation

July, 1994, Royal Women's Hospital, Melbourne, Personal Invitation

October, 1994, Department of Pharmacology, University of Melbourne

June, 1995, Prince Henry's Institute of Medical Research, Melbourne, Personal Invitation

September, 1995, Hebei Medical College, PRC, Personal Invitation

February, 1996, Boden Research Conference -Thredbo, NSW, Personal Invitation

November, 1996, Kumamoto University, Japan, Personal Invitation

December, 1996, ASCEPT New Investigators Symposium, Personal Invitation

September 1997, International Symposium of NO in health and diseases, Japan, Plenary lecturer.

Participation in National & International Conferences

1987, Australian Society of Clinical and Experimental Pharmacologists & Toxicologists

(ASCEPT), Hobart, Tasmania, (1 Poster Presentation)

1987, Xth International Congress of Pharmacology, Sydney (1 Poster Presentation)

1988, 5th SEA/WP Regional Meeting of Pharmacologists, Beijing, (1 Oral and 1 Poster)

1988, ASCEPT, Adelaide (1 Poster Presentation)

1989, APPS, Sydney (2 Poster Presentations)

1989, ASCEPT, Sydney (1 Poster Presentation)

1990, APPS, Brisbane (1 Poster Presentation)

1990, ASCEPT, Melbourne (1 Oral and 2 Poster Presentations)

1990, Australian Neuroscience Society Meeting, Melbourne, (1 Poster Presentation)

1991, APPS, Melbourne (1 Oral and 1 Poster Presentations)

1991, ASCEPT, Perth (1 Oral and 1 Poster presentations)

1992, APPS, Sydney (2 Oral and 3 Poster Presentations)

1992, ASCEPT, Sydney (2 Oral and 1 Poster Presentations)

1993, APPS, Melbourne (1 Poster Presentation)

1993, ASCEPT, Brisbane, Queensland (1 Oral and 2 Poster Presentations)

1993, Australian Neuroscience Society Meeting, Melbourne, (1 Oral Presentation)

1994, ASCEPT, New Zealand, (1 Oral and 3 poster presentations)

1994, International Congress of Pharmacology, Canada (1 Oral & 3 Poster Presentations)

1994, International Society of Hypertension Meeting, Melbourne (1 Poster Presentation)

1994, International Symposium on Nicotine, St. Adele, Canada (5 Poster Presentations)

1995, ASCEPT Meeting, Adelaide (5 Poster Presentations)

1995, British Pharmacological Society Meeting, (1 Oral Presentation)

1995, Chinese Pharmacology National Meeting, Chongqing, (1 Poster Presentation)

1995, International Meeting on the Biol. of Nitric Oxide, Florida, (2 Poster Presentations)

1996, ASCEPT & APPS Meeting, Melbourne (2 Oral and 7 Poster Presentations)

1996, Boden Research Conference -Thredbo, NSW (1 Oral Presentation)

1996, Experimental Biology 96, Am. Physiol. Soc., Washington, (1 Poster Presentation)

1997, International Symposium of NO in Health and Diseases, Japan (1 Presentation).

1997, The 5th Int. Meeting on the Biology of Nitric Oxide, Kyoto, Japan (5 Presentations)

1998, International Congress of Pharmacology, Germany (1 Poster Presentation)

1998, ASCEPT, Hobart, Tasmania, (1 Oral and 5 Poster Presentations)

1999, ASCEPT, Sydney (5 Presentations)

1999, Annual HBPRC Meeting on hypertension, Melbourne (2 presentations)

(f) Postgraduate and undergraduate Teaching

Experience in supervision of postgraduate students

BSC (Honour)

Rolls, K (1991) University of Melbourne (H2) (Supervisor)

Najbar, A (1992) University of Melbourne (H1) (Co-Supervisor)

Ellis, A. (1997) RMIT (H1) (Supervisor)

Karagiannis, J. (1998) RMIT (H1) (Supervisor)

PhD

Najbar, A (1993-1996) RMIT (Co-Supervisor)

Jiang, F. (1994-1999) (RMIT) (Supervisor)

Current Honours students

Siketa, J.R. (1999) RMIT (Supervisor)

Ng, Q.W. (1999) RMIT (Supervisor)

Current PhD students

Ellis, A. (1998-) RMIT (Supervisor)

Karagiannis, J. (1999-) RMIT (Supervisor)

Cherry Che, (1999-) RMIT (Supervisor)

Di Iulio, J.L (1996-2000) (RMIT) (Supervisor)

Current M.Sc students

L. Hong, J. (1999-) RMIT (Supervisor)

Experience in supervision of visiting scholars:

Dr. Brosch, S.F., (1992-1993) (Supervisor)

Department of Health, Austria

Professor W. Deng (1994,4 - 1994, 11) (Supervisor)

Chongqing Medical Research Institute P.R. China

Ms. Che C (1998-1999) (Supervisor)

P.R. China

Dr. Yoichi miyamoto (2000-)

Kumamoto University School of Medicine Japan

Experience in supervision of technical assistants:

(1991-1993) University of Melbourne:

William, M. (USA) (supervisor)

Di Iulio, J. (Australia) (supervisor)

Alexander, K. (UK) (supervisor)

Peer Review Experience

Referee for Scientific Journals:

European Journal of Pharmacology

Journal of Pharmacy and Pharmacology

Journal of Autonomic Pharmacology

British Journal of Pharmacology

Life Sciences

Research Grant Assessment

NHMRC

NHF

RMIT

Scientific Discipline

Membership of Professional Associations:

New York Academy of Science

Australian Society of Clinical and Experimental Pharmacologists & Toxicologists

International Society of Autonomic Neuroscience

Research Grant Support

Merck Sharp & Dohme Research Foundation

1995-1996. $40,000

RMIT University, Faculty of Biomed & Health Sci

1996. $15000

RMIT University, National Competitive Scheme

1997. $15,000

RMIT University, National Competitive Scheme

1997, $15,000

RMIT University, Faculty of Biomed & Health Sci

1998. $10,000

RMIT University, National Competitive Scheme

1999. $25000

2000. 18,000

2001. 18,000

Ramaciotti Foundation

Nitric oxide and prostate disease

1998, $15,000

RMIT University, Faculty of Biomed & Health Sci.

Estrogen and nitric oxide pathway

1999, $7000

The Wellcome Trust, Equipment Grant

Single cell electrophysiology/fluorescence analyser

1999, $262,616

NHMRC, Project grant

1999-2001, $297,000

RMIT University

Development of comprehensive database for Chinese medicinal herbs.

2000, $12000

National Hear foundation Grant

2000-2001, $75,000

Publications

Refereed Journal Articles

1. Li, C.G, Fu, S.X., Li Y.S. (1986) Effects of histamine on ouabain-induced ventricular fibrillation in guinea pigs. Acta Pharmacol. Sin., 7, 212-215.

2. Li, C.G. & Fu, S.X. (1986) Ultrastructural changes caused by histamine in normal and ischemic hearts of guinea-pigs. Commun. Pharmacol. Sin., 13, 15-16.

3. Wang, Y.L., Li, Y.S., Fu, S.X. & Li, C.G. (1986) Cardiovascular action and toxicity of nimodipine. Acta Acad. Med. Hebei., 7, 106-109.

4. Li, Y.S, Li, C.G. & Fu, S.X. (1986) Cardiovascular effects and toxicity of compound F-CO and F-OH, derived from a Chinese herbal product. Acta Acad. Med. Hebei., 7, 15-19.

5. Li, Y.S., Fu, S.X. & Li, C.G. (1987) Arrhythmogenic effects of histamine on ischemic heart of guinea-pigs. Acta Pharmacol. Sin. 8, 536-540.

6. Li, C.G., Fu, S.X., Li, Y.S., Xu, Y.F. (1988) Histamine contents in hearts and whole blood during early myocardial ischemia in three rodents. Acta Pharmacol. Sin. 8, 9:239-242.

7. Li, C.G., Majewski, H. Rand, M.J. (1988) Facilitation of noradrenaline release by prejunctional ?-adrenoceptors and angiotensin receptors in rat anococcygeus muscle. Br. J. Pharmacol., 95, 385-392.

8. Li C.G. & Rand, M.J. (1988) Rilmenidine acts as a partial agonist on prejunctional -2 adrenoceptors in guinea-pig atria. Clin. Exp. Physiol. Pharmacol., 15, 765-772.

9. Li C.G. & Rand, M.J. (1989) Prejunctional regulation of non-adrenergic and non-cholinergic transmission in rat anococcygeus muscle. Eur. J. Pharmacol., 168, 107-111.

10. Li C.G. & Rand, M.J. (1989) Rilmenidine differs from clonidine in that it lacks histamine-like activity. J. Pharm. Pharmacol., 41, 464-468.

11. Li, C.G. & Rand, M.J. (1989) Evidence for a role of nitric oxide in the neurotransmitter system mediating relaxation of the rat anococcygeus muscle. Clin. Exp. Physiol. Pharmacol., 16, 933-938.

12. Li, C.G. & Rand, M.J. (1990) Nitric oxide and VIP mediate NANC inhibitory transmission to smooth muscle of the rat gastric fundus. Eur. J. Pharmacol., 191, 303-309.

13. De Luca, A., Li, C.G., Rand, M.J., Reid, J.J., Thaina, P. & Wong-Dusting, H.K. (1990) Effects of omega-conotoxin GVIA on autonomic neuroeffector transmission in various tissues. Br. J. Pharmacol., 101, 437-447.

14. Li, C.G. & Rand, M.J. (1991) Evidence that part of the NANC relaxant response of guinea-pig trachea to electrical field stimulation is mediated by nitric oxide. Br. J. Pharmacol., 102, 91-94.

15. Rand, M.J. & Li, C.G. (1992) Activation of noradrenergic and nitrergic mechanism in the rat anococcygeus muscle by nicotine. Clin. Exp. Physiol. Pharmacol., 19, 103-111.

16. Rand, M.J. & Li, C.G. (1992) Effects of argininosuccicinic acid on nitric oxide mediated relaxations in rat aorta and anococcygeus muscle. Clin. Exp. Physiol. Pharmacol., 19, 331-334.

17. Li, C.G. Rand & M.J. (1993) Effects of hydroxocobalamin and haemoglobin on NO-mediated relaxations in the rat anococcygeus muscle. Clinical and Experimental Pharmacology and Physiology, 20, 633-640.

18. McLaren, A., Li, C.G. & Rand, M.J. (1993) Mediators of nicotine-induced relaxations of rat gastric fundus. Clinical and Experimental Pharmacology and Physiology, 20, 451-457.

19. Rajanayagam, M.A.S., Li, C.G. & Rand, M.J. (1993) Differential effects of hydroxocobalamin on NO-mediated relaxations is rat aorta and anococcygeus muscle. British Journal of Pharmacology, 108, 3-5.

20. Rand, M.J. & Li, C.G. (1993a) Differential effects of hydroxocobalamin on relaxations induced by nitrosothiols in rat aorta and anococcygeus muscle. European Journal of Pharmacology, 241, 249-254.

21. Rand, M.J. & Li, C.G. (1993b) The inhibition of nitric oxide-mediated relaxations in rat aorta and anococcygeus muscle by diphenylene iodonium. Clinical and Experimental Pharmacology and Physiology, 20, 141-148.

22. Rand, M.J. & Li, C.G. (1993c) Acetylcholine-induced contractions of the rat anococcygeus muscle are modulated by concurrent activation of nitrergic relaxation. British Journal of Pharmacology, 110, 1479-1482.

23. Li, C.G., Brosch, S. & Rand, M.J. (1994) Inhibition by ethacrynic acid of NO-mediated relaxations of the rat anococcygeus muscle. Clinical and Experimental Pharmacology and Physiology, 21, 293-299.

24. Najbar, A., Li, C.G. & Rand, M.J. (1994) Pharmacological actions of the coenzymes NAD(H) and NADP(H) on the rat anococcygeus muscle. Clinical and Experimental Pharmacology and Physiology, 21, 9-20.

25. Rand, M.J. & Li, C.G. (1994) Effects of ethanol and other aliphatic alcohols on NO-mediated relaxations in rat anococcygeus muscles and gastric fundus strips. British Journal of Pharmacology, 111, 1089-1094.

26. Rand, M.J. & Li, C.G. (1995) Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. British Journal of Pharmacology, 116, 1906-1910.

27. Li, C.G. & Rand, M.J. (1996) Inhibition of NO-mediated responses by 7-ethoxyreorufin, a substrate and competitive inhibitor of cytochrome P450. British Journal of Pharmacology, 118, 57-62.

28. La, M., Li, C.G. & Rand, M.J. (1996) Comparison of the effects of hydroxocobalamin and oxyhaemoglobin on responses to NO, EDRF and the nitrergic transmitter. British Journal of Pharmacology, 117, 805-810.

29. Najbar, A., Li, C.G. & Rand, M.J. (1996) Characterization of purinoceptors of the smooth muscle in the rat anococcygeus muscle. British Journal of Pharmacology, 118, 537-542.

30. Di Iulio, J., Li, C.G. & Rand, M.J. (1997) Determination of nitric oxide synthase activity in rat, pig and rabbit prostate glands. European Journal of Pharmacology, 337, 245-249.

31. Najbar-Kazkiel, A.T., Di Iulio, J., Li, C.G. & Rand, M.J. (1997) Characterisation of excitatory and inhibitory transmitter systems in prostate glands of rats, guinea-pigs, rabbits and pigs. European Journal of Pharmacology, 337, 251-258.

32. Jiang, F., Li, C.G. & Rand, M.J. (1997) Mechanisms of electrical field stimulation-induced vasodilatation in the guinea-pig basilar artery: the role of endothelium. Journal of Autonomic Pharmacology, 17, 71-76.

33. Jiang, F., Li, C.G. & Rand, M.J (1997) Effect of hydroxocobalamin on vascular responses to the nitrergic transmitter, nitric oxide and EDRF in guinea-pig isolated bassilar artery. European Journal of Pharmacology, 340, 181-186.

34. Ellis, A., Li, C.G. & Rand, M.J. (1998) Effect of xanthine oxidase inhibition on endothelium-dependent and nitrergic relaxations. European Journal of Pharmacology., 356, 41-47.

35. Jiang, F., Li, C.G. & Rand, M.J. (1998) Role of potassium channels in the nitrergic nerve stimulation-induced vasodilatation in the guinea-pig isolated basilar artery. British Journal of Pharmacology, 123, 106-112.

36. Deluca, A., Li, C.G. & Rand, M.J (`1999) Nitrergic and purinergic mechanisms for relaxation of the rat internal anal sphincter. Journal. Autonomic Pharmacology, 19, 1-9.

37. Jiang, F., Li, C.G. & Rand, M.J. (1999) Cholinergic prejenctional inhibition of nitrergic neurotransmission in the guinea-pig isolated basilar artery. Clinical and Experimental Pharmacology and Physiology, 26, 364-370.

38. Di Iulio, J.L., Gude, N.M., Li, C.G., Rand, M.J., King, R,G. & Brennecke, S.P. (1999) Placental nitric oxide synthase activity is not altered in human diabetes. Clinical science, in press.

39. Ellis, A., Li, C.G., Karagiannis J. & Rand, M.J. (1999) Differential actions of L-cysteine on responses to NO, EDNO and the nitrergic transmitter in the rat aorta and the anococcygeus muscle. British Journal of Pharmacology (in press).

40. Li, C.G. & Rand, M.J. (1999) Effects of hydroxocobalamin and carboxy-PTIO on nitrergic transmission in porcine anococcygeus and retractor penis muscles. British Journal of Pharmacology, 127, 172-176.

41. Li, C.G., Karagiannis J & Rand, M.J. (1999) Comparison of the redox forms of nitrogen monoxide with the nitrergic transmitter in the rat anococcygeus muscle. British Journal of Pharmacology, 127, 826-834.

Reviews

42. Li, C.G. Fu, S.X. & Li, Y.S. (1985) Effect of histamine on arrhythmia and its mechanism. Prog. Physiol. Sci., 16, 225-228.

43. Rand, M.J. & Li, C.G. (1995) Nitric oxide as neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission. Ann. Rev. Physiol. 57, 659-682.

44. Rand, M.J., Li, C.G., McLaren, A. & La, M. (1995) nitric oxide or an NO-adduct as an autonomic neurotransmitter. Plenary lecture (Manila, November) Proceedings of the 7th Southeast Asian/Western Pacific Regional Meeting of Pharmacologists. Pp. 23-27

45. Rand, M.J. & C.G. Li, M. La, A. De Luca, A., Najbar, F. Jiang, J. Di Iulio & A. Ellis (1997) Nitrergic transmission: discovery and continuing studies. Asia Pacific Journal of Pharmacology. 12, 137-148.

Book Chaptetrs

46. Rand, M.J. & Li, C.G. (1995) Nitric oxide in the autonomic and enteric nerves systems. In: Nitric Oxide in Nervous System, ed. S.R. Vincent, Academic Press, London, pp 228-279.

47. Rand, M.J. & Li, C.G. (1995) Role of the L-arginine-NO-cyclic GMP pathway in NANC neurotransmission. In: IUPHAR 94. ed. A.C. Cuuello & Collier. Birkhauser. pp. 355-362

Conference Papers or Abstracts

48. Jiang, F, Li, C.G. Rand, M.J. (1999) Large-conductance calcium-activated K+ channels are involved in EDHF-induced relaxations in the rat renal artery. The American Society of Hypertension, in press

49. Li, C.G, Rand, M.J., Akaike, T., Oshida, M. & Maeda, H. (1998) Activation of a nitrergic mechanism by black widow spider venom and -latrotoxin. In: The Biology of Nitric Oxide, Ed. S.Moncada et al. Part 6, 80.

50. Di Iulio, J.L., Li, C.G. & Rand, M.J. (1998) NO synthase and L-arginine metabolism in the rat, pig and rabbit prostate gland. In: The Biology of Nitric Oxide, Ed. S.Moncada et al. Part 6, 81.

51. Najbar-Kazkiel, A.T., Li, C.G. & Rand, M.J. (1998) Search for nitrergic mechanisms in isolated prostate glands of rat, guinea-pig, rabbit and pig. In: The Biology of Nitric Oxide, Ed. S.Moncada et al. Part 6, 82.

52. Tayama, S, Akaike, T., Tsunoda, R., Li, C.G., Rand, M.J., Yoshida, M., Yasue, H. & Maeda, H. (1998) characterization of EDRF response by using liposome PTIO: implication of nitrosothiol formation in EDRF response. In: The Biology of Nitric Oxide, Ed. S.Moncada et al. Part 6, 311.

53. Jiang, F., Li, C.G. & Rand, M.J. (1998) Role of K+ channels in the relaxant response to the nitrergic transmitter in isolated guinea-pig basilar arteries. In: The Biology of Nitric Oxide, Ed. S.Moncada et al. Part 6, 69.

52. Li, C.G. & Rand, M.J. (1998) Effect of melatonin in the rat anococcygeus muscle. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, 5, 105.

53. Najbar-Kazkiel, A.T, Di Iulio, J.L., Li, C.G. & Rand, M.J. (1998) Effect of 17-oestradiol (OES) on nitrergic and noradrenergic responses of castrated rat anococcygeus muscle. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, 5, 140.

54. Di Iulio, J.L., Najbar-Kazkiel, A.T, Li, C.G. & Rand, M.J. (1998) Effect of 17-oestradiol (OES) on neurogenic responses of the rat anococcygeus and gastric fundus muscles. Naunyn-Schmiedeberg's Archives of pharmacology, (Supplement 1), 358P, R297.

55. Karagiannis J., Li, C.G. & Rand, M.J. (1998) The effects of NO-redox forms on the rat anococcygeus muscle. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, 5, 192.

56. Ellis, A., Li, C.G. & Rand, M.J. (1998) Efects of L-cysteine on NO-mediated responses in the rat aorta and anococcygeus muscle. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, 5, 191.

57. Jiang, F., Li, C.G. & Rand, M.J. (1998) Endothelium-derived and NO-independent relaxations in the rat renal artery. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, 5, 46.

58. Rand, M.J., Di Iulo, J., Li, C.G. & Deng, W.L. (1998) Electrolytic degradation of L-arginine thwarted attempt to measure nitrergic tranmsission with radiotracer. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, 5, 105..

59. Li, C.G. Rand, M.J. Reid, A. De Luca, A. Najbar, F. Jiang, J. Di Iulio (1997) Nitrergic transmission. Proceedings of International Symposium on Nitric Oxide in Health and Diseases. 18P.

60. Jiang, F., Li, C.G. & Rand, M.J. (1997) Role of K+ channels in the relaxant response to the nitrergic transmitter in isolated guinea-pig basilar arteries. Japanese Journal of Pharmacology, 30P.

61. Li, C.G. & Rand, M.J. (1997) Activation of a nitrergic mechanism by black widow spider venom and -latrotoxin. Japanese Journal of Pharmacology, 33P.

62. Di Iulio, J.L., Li, C.G. & Rand, M.J. (1997) NO synthase and L-arginine metabolism in the rat, pig and rabbit prostate gland. Japanese Journal of Pharmacology, 33P.

63. Najbar-Kazkiel, A.T., Li, C.G. & Rand, M.J. (1997) Search for nitrergic mechanisms in isolated prostate glands of rat, guinea-pig, rabbit and pig. Japanese Journal of Pharmacology, 34P.

64. Tayama, S, Akaike, T., Tsunoda, R., Li, C.G., Rand, M.J., Yoshida, M., Yasue, H. & Maeda, H. (1997) characterization of EDRF response by using liposome PTIO: implication of nitrosothiol formation in EDRF response. Japanese Journal of Pharmacology, 112P.

65. Li, C.G, Shuttleworth, C.W.R. & Sander, K. (1997) Effects of low extracellular calcium and ODQ on the inhibitory junctional potential of the murine and dog proximal colon. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, in press.

66. Tayama, S. Akaike, T., Li, C.G., Rand, M.J., Yoshida, M. & Maeda, H. (1997) Comparison of the effects of liposome PTIO on EDRF activity in vitro and in vivo: reactions with thiols. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, in press.

67. Ellis, A., Li, C.G. & Rand, M.J. (1997) Modulation of endothelium-derived NO by superoxide generated by xanthine oxidase. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, in press.

68. Di, Iulio, J., Najbar-Kaszkiel, A., Li, C.G. & Rand, M.J. (1997) Effect of 17-oestradiol on nitric oxide synthase and arginase activity in the rat prostate gland. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, in press.

69. Jiang, F., Li, C.G. & Rand, M.J. (1997) Nitrergic transmitter-induced vasodilatation in the guinea-pig basilar artery is partly mediated by calcium-activated K+ channels. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, in press.

70. Najbar-Kazkiel, A.T., Di Iulio, J., Li, C.G. & Rand, M.J. (1997) Effects of 17-oestradiol on electrical stimulation induced responses in the rat isoalted anococcygeus muscle. Proceedings of the Australian Society for Clinical and Experimental Pharmacology and Toxicology, in press.

71. Li, C.G. & Rand, M.J. (1997) Release of the nitrergic transmitter by -latrotoxin. Proceeding of Australian Neuroscience Society. in press.

72. Li, C.G. (1996) Development of the concept of nitrergic transmission.. Proceedings of the Australasian Society for Clinical and Experimental Pharmacology and Toxicology, 3, 7.

73. Li C.G. & Rand, M.J. (1996) Effects of colchicine and black widow spider venom on noradrenergic and nitrergic responses in the rat anococcygeus muscle: evidence for exocytosis in transmitter systems. Proceedings of the Australasian Society for Clinical and Experimental Pharmacology and Toxicology, 3, 30.

74. Li, CG (1996). Functional Evidence for nitrergic transmission. Second Boden Research Conference, Nitric Oxide in the Nervous System. Thredbo, Australia.

75. Li, C.G. Gerraty, N. & Rand, M.J. (1996) Effects of hydroxocobalamin and carboxy-PTIO on nitrergic transmission in porcine anococcygeus and retractor penis muscles. Proceedings of the Australian Physiological and Pharmacological Society, 27, 167P.

76. Najbar-Kaszkiel, A. T., Li, C.G. & Rand, M.J. (1996) Effects of McN-A-343 (MN) on noradrenergic contractions of rat anococcygeus muscle. Proceedings of the Australian Physiological and Pharmacological Society, 27, 169P.

77. Najbar-Kaszkiel, A. T., Li, C.G. & Rand, M.J. (1996) Characterisation of transmitter systems in isolated prostate glands of rats, guinea-pigs, pigs and rabbits. Proceedings of the Australasian Society for Clinical and Experimental Pharmacology and Toxicology, 3, 110.

78. Jiang, F., Li, C.G. & Rand, M.J. (1996) Differential sensitivity of the nitrergic transmitter and EDRF to the NO scavengers hydroxocobalamin and carboxy-PTIO in guinea-pig basilar arteries. Proceedings of the Australian Physiological and Pharmacological Society, 27, 172P.

79. Jiang, F., Li, C.G. & Rand, M.J. (1996) Participation of endothelium in the vasodilator response to nerve stimulation in the guinea-pig basilar artery. Proceedings of the Australasian Society for Clinical and Experimental Pharmacology and Toxicology, 3, 31.

80. De Luca, A, Li, CG & Rand, MJ (1996) 'Studies into nitrergic neuroeffector transmission in sphincters of the gastrointestinal system of the rat. Second Boden Research Conference, Nitric Oxide in the Nervous System. Thredbo, Australia.

81. Di Iulio, J.L., Li, C.G., Falckh, P.H.J. & Rand, M.J. (1996) Characterisation of enzymes that convert l-arginine to l-citrulline in the rat, pig and rabbit prostate glands. Proceedings of the Australasian Society for Clinical and Experimental Pharmacology and Toxicology, 3, 111

82. Rand, M.J. & Li, C.G. (1996) Is the NO adduct of ergothioneine the nitrergic transmitter in the rat ano-coccygeus muscle? Proceedings of the Australian Physiological & Pharmacological Society, 27, 168P.

83. La, M., Li, C.G. & Rand, M.J. (1996) Release of nitric oxide from nitrergic nerves of the guinea-pig small intestine using a bioassay system. Experimental Biology 96, American Physiological Society, Washington, April.

84. Li, C.G., De Luca, M., La, M. & Rand, M.J. (1995) Lack of effect of the nNOS inhibitor bromo-7-nitro-indazole on nitrergic relaxations of the rat anococcygeus muscle. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 2, 142.

85. Jiang, F., Li, C.G. & Rand, M.J. (1995) Nitrergic mechanisms in guinea-pig cerebral arteries. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 2, 81.

86. Najbar, A., Li, C.G. & Rand, M.J. (1995) Evidence for P2-purinoceptors subserving contraction to adenosine-5'-O-(2-thiophosphate) (ADPS) in the rat. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 2, 144.

87. Rand, M.J., De Luca, A., Fabiani, M.E. & Li, C.G. (1995) Apparent essential role of a neuronal-type nicotinic receptor in nitregic transmission in the rat anal sphincter. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 2, 45.

88. Rand, M.J. & Li, C.G. (1995) Effects of cytochrome P450 inhibitors on nitric oxide synthase-dependent responses in rat aorta and anococcygeus muscle. British Journal of Pharmacology, 116, 318P.

89. Rand, M.J., Li, C.G. & La, M. (1995) The nitrergic transmitter differs from EDRF. Fourth International Meeting on the Biology of Nitric Oxide, Florida, September. Endothelium, 3, s77 (Abs. 303).

90. Rand, M.J., Li, C.G., McLaren, A. & De Luca, A. (1995) Nitrergic nerves in the enteric and autonomic nervous systems are a major target for nicotine. Fourth International Meeting on the Biology of Nitric Oxide, Florida, September. Endothelium, 3, s77 (Abs. 304).

91. Rand, M.J., Li, C.G., McLaren, A. & La, M. (1995) The physiology and pharmacology of nitrergic mechanisms. Invited lecture, Fifth National Meeting on Herbal Pharmacology, Chinese Pharmacological Society, Chongqing, November.

92. La, M, Li, CG & Rand, MJ (1995). Release of nitric oxide upon stimulation of nitrergic nerves in the guinea-pig small intestine in a bioassay system. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 2, 45.

93. Li, C.G., Brosch, S.F. & Rand, M.J. (1994) Inhibition of relaxations of the rat anococcygeus muscle to NO, nitrergic nerve stimulation, nitrosothiols and other NO-donors by ethacrynic acid. Canadian Journal of Physiology and Pharmacology, 72 (Suppl. 1), 465.

94. Li, C.G. & Rand, M.J. (1994) Inhibition of nitric oxide-mediated vasodilatation and nitrergic transmission by the cytochrome P450 inhibitor 7-ethoxyresorufin. 15th Scientific Meeting, International Society of Hypertension, Melbourne, March. Abstract 189, p. S33.

95. Li, C.G. & Rand, M.J. (1994) Effects of carboxy PTIO on NO-mediated responses in rat aorta, anococcygeus muscle and gastric fundus. Proceedings of the Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists, 1, 73.

96. Li, C.G. & Rand, M.J. (1994) The actions of DMPP on noradrenergic mechanisms differ from those of nicotine in the rat anococcygeus muscle. The Effects of Nicotine on Biological Systems. International Symposium on Nicotine, St. Adele, Canada, July. Abstract P83.

97. McLaren, A., Li, C.G. & Rand, M.J. (1994) Nicotinic activation of multiple transmitter systems from intrinsic neurons of the rat gastric fundus. The Effects of Nicotine on Biological Systems. International Symposium on Nicotine, St. Adele, Canada, July. Abstract P81.

98. McLaren, A., Li, C.G. & Rand, M.J. (1994) Nicotine-induced relaxations of rat gastric fundus involves parathyroid hormone-related peptide. The Effects of Nicotine on Biological Systems. International Symposium on Nicotine, St. Adele, Canada, July. Abstract P82.

99. Najbar, A., Li, C.G. & Rand, M.J. (1994) Actions of NADP and ATP in rat anococcygeus muscle, rat aorta and guinea-pig taenia caeci. Canadian Journal of Physiology and Pharmacology, 72 (Suppl. 1), 505.

100. Najbar, A., Li, C.G. & Rand, M.J. (1994) P2-Purinoceptors in the rat anococcygeus muscle. Proceedings of the Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists, 1, 89.

101. Rand, M.J., Li, C.G. & McLaren, A. (1994) A new major target for nicotine: nitrergic nerves. The Effects of Nicotine on Biological Systems. International Symposium on Nicotine, St. Adele, Canada, July. Abstract P85.

102. Rand, M.J., Li, C.G. & McLaren, A. (1994) Effects of cysteine on nicotine-, nitric oxide- and stimulation-induced relaxations in the rat gastric fundus. Canadian Journal of Physiology and Pharmacology, 72 (Suppl. 1), 480.

103. Li, C.G. & Rand, M.J. (1994) Nicotinic activation of nitrergic nerves in the anococcygeus muscle: a model system for studying nitrergic transmission. The Effects of Nicotine on Biological Systems. International Symposium on Nicotine, St. Adele, Canada, July. Abstract P84.

104. Rand, M.J. & Li, C.G. (1994) New perspectives in NANC neurotransmission. Canadian Journal of Physiology and Pharmacology, 72 (Suppl. 1), S55.4.

105. Rand, M.J. & Li, C.G. (1994) The nature of the nitrergic transmitter and the mechanism of transmission at neuroeffector junctions. Proc. of 1st International Conference, Biochemistry and molecular biological of nitric oxide. LA, U.S.A. 107.

106. Rand, M.J. & Li, C.G. (1994) Effects of 7-nitroindazole, ebeselen and thimerosal on nitrergic transmission in the rat anococcygeus muscle. Proceedings of the Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists, 1, 101.

107. Brosch, S.F., Rand, M.J. & Li, C.G. (1993) Ethacrynic acid inhibits relaxations of the rat anococcygeus muscle elicited by nitrergic nerve stimulation, sodium nitroprusside and glyceryl trinitrate. Proceedings of the Australian Physiological and Pharmacological Society, 24, 89P.

108. Li, C.G. & Rand, M.J. (1993) Inhibition of NO-mediated vasodilatation by the cytochrome P450 inhibitor 7-ER. Clinical and Experimental Pharmacology and Physiology, Suppl. 1, 43.

109. McLaren, A.M., Li, C.G. & Rand, M.J. (1993) Is parathyroid hormone-related peptide (PTHrP) involved in nicotine-induced relaxations of rat gastric fundus? Clinical and Experimental Pharmacology and Physiology, Suppl. 1, 46.

110. Li, C.G. (1993) nitric oxide as a neurotransmitter: evidence and questions. Proceedings of the Australian Neuroscience Society, 4, 21, SYM-3-6.

111. Rand, M.J. & Li, C.G. (1993) Effects of the cytochrome P450 inhibitor 7-ER on relaxations to nitrergic nerve stimulation and exogenous nitric oxide. Clinical and Experimental Pharmacology and Physiology, Suppl. 1, 59.

112. Rand, M.J. & Li, C.G. (1992) Differential effects of cyteine and glutathione on NO- and stimulation-induced relaxations of the rat anococcygeus muscle. Proceedings of the Australian Physiological and Pharmacological Society, 23, 175.

113. Li, C.G. & Rand, M.J. (1992) Effects of hydroxocoballamin on nitric oxide (NO)-mediated relaxations in the rat anococcygeus muscle. Clinical and Experimental Pharmacology and Physiology, Suppl. 21, 39.

114. Rand, M.J. & Li, C.G. (1992) Differential effects of hydroxocobalamin on relaxations induced by nitrosothiols. Clinical and Experimental Pharmacology and Physiology, Suppl. 21, 57.

115. Najbar, A. & Li, C.G. (1992) Mechanism of relaxant action of NADPH in rat anococcygeus muscle. Clinical and Experimental Pharmacology and Physiology, Suppl.21, 51.

116. Najbar, A. Li, C.G. & Rand, M.J. (1992) Pharmacological actions of nicotinamide-adenine dinucleotides (NAD, NADH, NADP and NADPH) on the rat anococcygeus muscle. Proceedings of the Australian Physiological and Pharmacological Society, 23, 210.

117. McLerence, A., Li, C.G. & Rand, M.J. (1992) Cysteine differentially affects nicotine- and nitric oxide induced relaxations in rat gastric fundus. Proceedings of the Australian Physiological and Pharmacological Society, 23, 176.

118. Li, C.G. & Rand, M.J. (1992) Hydroxocobalamin inhibits relaxations of rat anococcygeus muscle elicited by nitric oxide and sodium nitroprusside but not those elicited by nitrergic nerve stimulation or nitrosothiols. Proceedings of the Australian Physiological and Pharmacological Society, 23, 196.

119. Jenkinson, K.M., Reid, J.J., Rajanayagam, A.S., Li, C.G. & Rand, M.J. (1992) Hydroxocobalamin differentially inhibits relaxations of rat gastric fundus strips to sodium nitroprusside and non-adrenergic non-cholinergic nerve stimulation. Proceedings of the Australian Physiological and Pharmacological Society, 23, 195.

120. McLerence, A., Li, C.G. & Rand, M.J. (1992) Are nicotine-induced relaxations of the rat gastric fundus mediated by vasoactive intestinal polypeptides as well as nitric oxide. . Proceedings of the Australian Physiological and Pharmacological Society, 23, 8.

121. Rolls, K., Li, C.G. & Rand, M.J. (1991) Effects of captopril on contractions induced by bradykinin, substance P and neurokinin A in guinea-pig lung and rat gastric fundus. . Proceedings of the Australian Physiological and Pharmacological Society, 22, 184.

122. Rolls, K. & Li, C.G. (1991) Effects of prideprilat on contractions induced by bradykinin, substance P and neurokinin A in guinea-pig ling and rat gastric fundus. . Clinical and Experimental Pharmacology and Physiology, Suppl. 18, 53.

123. Li, C.G. & Rand, M.J. (1991) Inhibition of nitrergic relaxations by diphenylene iodonium in rat anococcygeus muscle and aorta. . Clinical and Experimental Pharmacology and Physiology, Suppl. 18, 36.

124. Li, C.G. & Rand, M.J. (1991) Inhibition of neuronally-mediated nitrergic relaxations by ethanol and acetadehyde in rat gastric fundus and anococcygeus muscle. Proceedings of the Australian Physiological and Pharmacological Society, 22, 103.

125. Reid, J.J.,De Luca, A., Li, C.G., Rand, M.J., Thaina, P. & Wong-Dusting, H.K. (1990) A profile of the effects of omega-conotoxin GVIA on peripheral neuroeffector transmission in various tissues. Eur. J. Pharmacol., 183, 2040-2041.

126. Rand, M.J. & Li, C.G. (1990) Nitric oxide mediates non-adrenergic non-cholinergic relaxation in some neuroeffector systems: examples of nitrergic transmission. Eur. J. Pharmacol., 183, 1144.

127. Rand, M.J. & Li, C.G. (1990) Prejunctional modulation of nitrergic neurotransmission. Presynaptic Receptors and Neuronal Transporters, Rouen.

128. Li, C.G. & Rand, M.J. (1990) Evidence suggesting that nitric oxide mediates NANC neurotransmission in rat gastric fundus and anococcygeus. Clinical and Experimental Physiology & Pharmacology, Suppl. 16, 184.

129. Li, C.G. & Rand, M.J. (1990) Non-adrenergic, non-cholinergic (NANC) relaxations of guinea-pig tracheal smooth muscle are blocked by inhibitors of nitric oxide synthesis. Proceedings of the Australian neuroscience Society, vol 1 (10th Ann. Meeting), 100P.

130. Li, C.G. & Rand, M.J. (1990) Postjunctional but not prejunctional 2-adrenoceptors in rat anococcygeus muscle are coupled with a pertussis toxin-sensitive system. Proceedings of the Australia Physiological and Pharmacological Society, 21, 10P.

131. Li, C.G. & Rand, M.J. (1990) Effect of capsaicin on the non-adrenergic non-cholinergic neurotransmission in rat anococcygeus muscle. Clinical and Experimental Physiology & Pharmacology, Suppl. 17, 44.

132. Li, C.G. & Rand, M.J. (1990) Effects of omega-conotoxin GVIA on NANC transmission. Clinical and Experimental Physiology & Pharmacology, Suppl. 16, 84.

133. Li, C.G. & Rand, M.J. (1989) Prejunctional inhibition of non-adrenergic, non-cholinergic (NANC) transmission in rat anococcygeus muscle. Clinical and Experimental Pharmacology and Physiology, Suppl. 14, 152.

134. Li, C.G. & Rand, M.J. (1989) Lack of evidence for an interaction between prejunctional 2-adrenoceptors and nicotinic cholinoceptors on noradrenergic nerve terminals in rat isolated atria. Proceedings of the Australian Physiological and Pharmacological Society, 20, 71P.

135. Li, C.G. & Rand, M.J. (1989) Evidence that nitric oxide is a neurotransmitter mediating the stimulation-induced relaxation of the rat anococcygeus muscle. Proceedings of the Australian Physiological and Pharmacological Society, 20, 197P.

136. Li, C.G. & Rand, M.J. (1988) Effects of rilmenidine on guinea-pig atria and rat uterus. Proceedings of 5th SEA/WP Regional Meeting of Pharmacologists, S.32.05.

137. Li, C.G. & Rand, M.J. (1988) Effects of tetradecapeptide renin substrate on sympathetic transmission in rat isolated anococcygeus muscle. Proceedings of 5th SEA/WP Regional Meeting of Pharmacologists, O.23.03.

138. Li, C.G. Majewski, H. & Rand, M.J. (1987) ?-adrenoceptor-mediated facilitatory effects on noradrenaline release in rat anococcygeus muscle. Xth International Congress of Pharmacology, Sydney.

139. Li, C.G. & Rand, M.J. (1987) Oxaminazoline acts as a partial agonist on prejunctional -adrenoceptors in guinea-pig atria. Clinical and Experimental Physiology & Pharmacology, Suppl. 12, 35.